For patients with a history of opioid use, which medications are listed?

For patients with a history of opioid use, which medications are listed?

• A. Orlistat
• B. Phentermine/topiramate, lorcaserin, liraglutide, orlistat
• C. Metformin
• D. Lorcaserin

Answer: (B)

Weight-management pharmacotherapy offers multiple agents with different mechanisms to help patients lose weight, and a history of opioid use does not automatically exclude these options. The comprehensive list includes four medications: phentermine/topiramate, lorcaserin, liraglutide, and orlistat. Phentermine/topiramate combines an appetite suppressant with a weight-loss–promoting anticonvulsant. Lorcaserin acts on serotonin 2C receptors to increase satiety. Liraglutide is a GLP-1 receptor agonist that slows gastric emptying and enhances fullness, aiding weight loss and metabolic control. Orlistat inhibits fat absorption in the gut, producing weight loss with gastrointestinal side effects. The other choices omit one or more of these agents or include a medication like metformin, which is used primarily for diabetes rather than obesity pharmacotherapy. Therefore, the option listing all four medications is the best fit.

Weight-management pharmacotherapy offers multiple agents with different mechanisms to help patients lose weight, and a history of opioid use does not automatically exclude these options. The comprehensive list includes four medications: phentermine/topiramate, lorcaserin, liraglutide, and orlistat. Phentermine/topiramate combines an appetite suppressant with a weight-loss–promoting anticonvulsant. Lorcaserin acts on serotonin 2C receptors to increase satiety. Liraglutide is a GLP-1 receptor agonist that slows gastric emptying and enhances fullness, aiding weight loss and metabolic control. Orlistat inhibits fat absorption in the gut, producing weight loss with gastrointestinal side effects. The other choices omit one or more of these agents or include a medication like metformin, which is used primarily for diabetes rather than obesity pharmacotherapy. Therefore, the option listing all four medications is the best fit.