Which hormone produced by the pancreas is anorexigenic?

Which hormone produced by the pancreas is anorexigenic?

• A. Insulin
• B. Ghrelin
• C. Leptin
• D. PYY

Answer: (A)

The question tests how pancreatic hormones regulate appetite, specifically which hormone reduces hunger after meals. Insulin, produced by the beta cells of the pancreatic islets, rises when blood glucose increases following a meal. In the brain, insulin binds to receptors in the hypothalamus and shifts activity away from hunger-promoting signals toward satiety signals. It dampens the activity of orexigenic neurons (like NPY/AgRP) and enhances signals from anorexigenic pathways (such as POMC), contributing to the feeling of fullness and reduced appetite. Other choices come from different tissues: ghrelin is made in the stomach and stimulates appetite; leptin comes from fat tissue and generally suppresses hunger but is not produced by the pancreas; peptide YY is released from the gut after eating and also reduces appetite. Since the question specifies a pancreatic hormone that decreases appetite, insulin is the best answer.

The question tests how pancreatic hormones regulate appetite, specifically which hormone reduces hunger after meals. Insulin, produced by the beta cells of the pancreatic islets, rises when blood glucose increases following a meal. In the brain, insulin binds to receptors in the hypothalamus and shifts activity away from hunger-promoting signals toward satiety signals. It dampens the activity of orexigenic neurons (like NPY/AgRP) and enhances signals from anorexigenic pathways (such as POMC), contributing to the feeling of fullness and reduced appetite.

Other choices come from different tissues: ghrelin is made in the stomach and stimulates appetite; leptin comes from fat tissue and generally suppresses hunger but is not produced by the pancreas; peptide YY is released from the gut after eating and also reduces appetite. Since the question specifies a pancreatic hormone that decreases appetite, insulin is the best answer.